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bioRxiv · 10.1101/2022.01.27.477838

Cueing motor memory reactivation during NREM sleep engenders learning-related changes in precuneus and sensorimotor structures

Rakowska, M.·Bagrowska, P.·Lazari, A.·Navarrete, M.·Abdellahi, M. E. A.·Johansen-Berg, H.·Lewis, P. A.
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Abstract

Memory reactivation during Non-Rapid Eye Movement (NREM) sleep is important for memory consolidation but it remains unclear exactly how such activity promotes the development of a stable memory representation. We used Targeted Memory Reactivation (TMR) in combination with longitudinal structural and functional MRI to track the evolution of a motor memory trace over 20 days. We show that repeated reactivation of motor memory during sleep leads to increased precuneus activation 24 h post-TMR. Interestingly, a decrease in precuneus activity over the next 10 days predicts longer-term cueing benefit. We also find both functional and structural changes in sensorimotor cortex in association with effects of TMR 20 days post-encoding. These findings demonstrate that TMR can engage precuneus in the short-term while also impacting on task-related structure and function over longer timescales.

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Rakowska, M., Bagrowska, P., Lazari, A., Navarrete, M., Abdellahi, M. E. A., Johansen-Berg, H., Lewis, P. A.. 2022-01-28. Cueing motor memory reactivation during NREM sleep engenders learning-related changes in precuneus and sensorimotor structures. https://doi.org/10.1101/2022.01.27.477838

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