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bioRxiv · 10.1101/2022.01.17.476664

The Streptococcus agalactiae R3 surface protein is encoded by sar5

Dragset, M. S.·Basson, A.·Olaisen, C.·Selvik, L.-K.·Lyng, R. V.·Lysvand, H.·Aas, C. G.·Afset, J. E.
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Abstract

Streptococcus agalactiae (a group B streptococcus; GBS) is an important human pathogen causing pneumonia, sepsis and meningitis in neonates, as well as infections in pregnant women, immunocompromised individuals, and the elderly. For the future control of GBS-inflicted disease, GBS surface exposed proteins are particularly relevant as they may act as antigens for vaccine development and/or as serosubtype markers in epidemiological settings. Even so, the genes encoding some of the surface proteins established as serosubtype markers by antibody-based methods are still unknown. Here, we identify sar5 as the gene encoding the R3 surface protein, a serosubtype marker of hitherto unknown genetic origin.

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Dragset, M. S., Basson, A., Olaisen, C., Selvik, L.-K., Lyng, R. V., Lysvand, H., Aas, C. G., Afset, J. E.. 2022-01-17. The Streptococcus agalactiae R3 surface protein is encoded by sar5. https://doi.org/10.1101/2022.01.17.476664

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