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bioRxiv · 10.1101/2022.01.15.476482

Population-specific association of Clock gene polymorphism with annual cycle timing in stonechats

Abstract

Timing is essential for survival and reproduction of organisms across the tree of life. The core circadian clock gene Clk has been implicated in annual timing and shows highly conserved sequence homology across vertebrates except for one variable region of poly Glutamine repeats. Clk genotype varies in some species with latitude, seasonal timing and migration. However, findings are inconsistent, difficult to disentangle from environmental responses, and biased towards high latitudes. Here we combine field data with a common-garden set up to study associations of Clk with latitude, migration and annual-cycle timing within the stonechat species complex with trans-equatorial distribution range. Including 950 individuals from nine populations with diverse migratory strategies. Gene diversity was lowest in resident African and Canary Island populations and increased with latitude, independently of migration distance. Repeat length and annual-cycle timing was linked in a population-specific way. Specifically, equatorial African stonechats showed delayed timing with longer repeat length for all annual-cycle stages. Our data suggest that at low latitudes with constant photoperiod, Clk genotype might orchestrate a range of consistent, individual chronotypes. In contrast, the influence of Clk on annual-cycle timing at higher latitudes might be mediated by its interactions with genes involved in (circadian) photoperiodic pathways.

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BibTeXRIS

Justen, H., Hasselmann, T., Illera, J. C., Delmore, K. E., Serrano, D., Flinks, H., Senzaki, M., Kawamura, K., Helm, B., Liedvogel, M.. 2022-01-17. Population-specific association of Clock gene polymorphism with annual cycle timing in stonechats. https://doi.org/10.1101/2022.01.15.476482

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