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bioRxiv · 10.1101/2022.01.06.475265

An emergent temporal basis set robustly supports cerebellar time-series learning

Abstract

Learning plays a key role in the function of many neural circuits. The cerebellum is considered a learning machine essential for time interval estimation underlying motor coordination and other behaviors. Theoretical work has proposed that the cerebellums input recipient structure, the granule cell layer (GCL), performs pattern separation of inputs that facilitates learning in Purkinje cells (P-cells). However, the relationship between input reformatting and learning outcomes has remained debated, with roles emphasized for pattern separation features from sparsification to decorrelation. We took a novel approach by training a minimalist model of the cerebellar cortex to learn complex time-series data from naturalistic inputs, in contrast to traditional classification tasks. The model robustly produced temporal basis sets from naturalistic inputs, and the resultant GCL output supported learning of temporally complex target functions. Learning favored surprisingly dense granule cell activity, yet the key statistical features in GCL population activity that drove learning differed from those seen previously for classification tasks. Moreover, different cerebellar tasks were supported by diverse pattern separation features that matched the demands of the tasks. These findings advance testable hypotheses for mechanisms of temporal basis set formation and predict that population statistics of granule cell activity may differ across cerebellar regions to support distinct behaviors.

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BibTeXRIS

Gilmer, J. I., Farries, M. A., Kilpatrick, Z. P., Delis, I., Person, A. L.. 2022-01-06. An emergent temporal basis set robustly supports cerebellar time-series learning. https://doi.org/10.1101/2022.01.06.475265

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