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bioRxiv · 10.1101/2022.01.04.474803

A synthetic bispecific antibody capable of neutralizing SARS-CoV-2 Delta and Omicron

Yuan, T. Z.·Lucas, C.·Monteiro, V. S.·Iwasaki, A.·Yang, M. L.·Nepita, H. F.·Lujan Hernandez, A. G.·Taft, J. M.·Frei, L.·Reddy, S. T.·Weber, C.·Malobisky, K. P.·Mesquita, R.·Sato, A.
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Abstract

Bispecific antibodies have emerged as a promising strategy for curtailing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immune escape. This brief report highlights RBT-0813 (also known as TB493-04), a synthetic, humanized, receptor-binding domain (RBD)-targeted bispecific antibody that retains picomolar affinity to the Spike (S) trimers of all major variants of concern and neutralizes both SARS-CoV-2 Delta and Omicron in vitro.

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Yuan, T. Z., Lucas, C., Monteiro, V. S., Iwasaki, A., Yang, M. L., Nepita, H. F., Lujan Hernandez, A. G., Taft, J. M., Frei, L., Reddy, S. T., Weber, C., Malobisky, K. P., Mesquita, R., Sato, A.. 2022-01-04. A synthetic bispecific antibody capable of neutralizing SARS-CoV-2 Delta and Omicron. https://doi.org/10.1101/2022.01.04.474803

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