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bioRxiv · 10.1101/2021.12.17.472912

Analysis of SARS-CoV-2 synonymous codon usage evolution throughout the COVID-19 pandemic.

Mogro, E. G.·Bottero, D.·Lozano, M. J.
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Abstract

SARS-CoV-2, the seventh coronavirus known to infect humans, can cause severe life-threatening respiratory pathologies. To better understand SARS-CoV-2 evolution, genome-wide analyses have been made, including the general characterization of its codons usage profile. Here we present a bioinformatic analysis of the evo-lution of SARS-CoV-2 codon usage over time using complete genomes collected since December 2019. Our results show that SARS-CoV-2 codon usage pattern is antagonistic to, and it is getting farther away from that of the human host. Further, a selection of deoptimized codons over time, which was accompanied by a decrease in both the codon adaptation index and the effective number of codons, was observed. All together, these findings suggest that SARS-CoV-2 could be evolving, at least from the perspective of the synonymous codon usage, to become less pathogenic. Graphical Abstract O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=92 SRC="FIGDIR/small/472912v1_ufig1.gif" ALT="Figure 1"> View larger version (29K): org.highwire.dtl.DTLVardef@d9d710org.highwire.dtl.DTLVardef@1b66a3corg.highwire.dtl.DTLVardef@f89a6eorg.highwire.dtl.DTLVardef@162d443_HPS_FORMAT_FIGEXP M_FIG C_FIG

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Mogro, E. G., Bottero, D., Lozano, M. J.. 2021-12-20. Analysis of SARS-CoV-2 synonymous codon usage evolution throughout the COVID-19 pandemic.. https://doi.org/10.1101/2021.12.17.472912

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