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bioRxiv · 10.1101/2021.12.15.472822

Protein Posttranslational Signatures Identified in COVID-19 Patient Plasma

Vedula, P.·Tang, H.-Y.·UPenn COVID Processing Unit,·Speicher, D.·Kashina, A.
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Abstract

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a highly contagious virus of the coronavirus family that causes coronavirus disease-19 (COVID-19) in humans and a number of animal species. COVID-19 has rapidly propagated in the world in the past 2 years, causing a global pandemic. Here, we performed proteomic analysis of plasma samples from COVID-19 patients compared to healthy control donors in an exploratory study to gain insights into protein-level changes in the patients caused by SARS-CoV-2 infection and to identify potential proteomic and posttranslational signatures of this disease. Our results suggest a global change in protein processing and regulation that occurs in response to SARS-CoV-2, and the existence of a posttranslational COVID-19 signature that includes an elevation in threonine phosphorylation, a change in glycosylation, and a decrease in arginylation, an emerging posttranslational modification not previously implicated in infectious disease. This study provides a resource for COVID-19 researchers and, longer term, will inform our understanding of this disease and its treatment. Key PointsO_LIPlasma from COVID-19 patients exhibits prominent protein- and peptide-level changes C_LIO_LIProteins from COVID-19 patient plasma exhibit prominent changes in several key posttranslational modifications C_LI

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Vedula, P., Tang, H.-Y., UPenn COVID Processing Unit,, Speicher, D., Kashina, A.. 2021-12-16. Protein Posttranslational Signatures Identified in COVID-19 Patient Plasma. https://doi.org/10.1101/2021.12.15.472822

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