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bioRxiv · 10.1101/2021.12.13.472476

Potential cross-protection against SARS-CoV-2 from previous exposure to bovine coronavirus

Querne, L. B. P.·Bastos, F. Z.·Beirao, B. C. B.
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Abstract

Humans have long shared infectious agents with cattle, and the common cold OC-43 CoV is a not-so-distant example of cross-species viral spillover. Human exposure to BCoV is certainly common, as the virus is endemic in cattle-raising regions. This article shows an in silico investigation of shared viral epitopes between BCoV and SARS-CoV-2. HLA recognition and lymphocyte reactivity were assessed using freely-available resources. Several epitopes were shared between BCoV and SARS-CoV-2, both for B and T lymphocytes. These data demonstrate that possible cross-protection is being induced by human exposure to cattle.

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Querne, L. B. P., Bastos, F. Z., Beirao, B. C. B.. 2021-12-14. Potential cross-protection against SARS-CoV-2 from previous exposure to bovine coronavirus. https://doi.org/10.1101/2021.12.13.472476

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