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bioRxiv · 10.1101/2021.12.08.471785

DISA tool: discriminative and informative subspace assessment with categorical and numerical outcomes

Alexandre, L. D. R.·Costa, R. S.·Henriques, R.
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Abstract

MotivationPattern discovery and subspace clustering play a central role in the biological domain, supporting for instance putative regulatory module discovery from omic data for both descriptive and predictive ends. In the presence of target variables (e.g. phenotypes), regulatory patterns should further satisfy delineate discriminative power properties, well-established in the presence of categorical outcomes, yet largely disregarded for numerical outcomes, such as risk profiles and quantitative phenotypes. ResultsDISA (Discriminative and Informative Subspace Assessment), a Python software package, is proposed to assess patterns in the presence of numerical outcomes using well-established measures together with a novel principle able to statistically assess the correlation gain of the subspace against the overall space. Results confirm the possibility to soundly extend discriminative criteria towards numerical outcomes without the drawbacks well-associated with discretization procedures. A case study is provided to show the properties of the proposed method. AvailabilityDISA is freely available at https://github.com/JupitersMight/DISA under the MIT license. Contact{leonardoalexandre@tecnico.ulisboa.pt,rmch@tecnico.ulisboa.pt} and {rs.costa@fct.unl.pt}

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Alexandre, L. D. R., Costa, R. S., Henriques, R.. 2021-12-10. DISA tool: discriminative and informative subspace assessment with categorical and numerical outcomes. https://doi.org/10.1101/2021.12.08.471785

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