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bioRxiv · 10.1101/2021.11.09.466986

Attractor Landscapes as a Model Selection Criterion in Data Poor Environments

Lyman, C. A.·Richman, S.·Morris, M. C.·Cao, H.·Scerri, A.·Cheadle, C.·Broderick, G.
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Abstract

Modeling of systems for which data is limited often leads to underdetermined model identification problems, where multiple candidate models are equally adherent to data. In such situations additional optimality criteria are useful in model selection apart from the conventional minimization of error and model complexity. This work presents the attractor landscape as a domain for novel model selection criteria, where the number and location of attractors impact desirability. A set of candidate models describing immune response dynamics to SARS-CoV infection is used as an example for model selection based on features of the attractor landscape. Using this selection criteria, the initial set of 18 models is ranked and reduced to 7 models that have a composite objective value with a p-value < 0.05. Additionally, the impact of pharmacologically induced remolding of the attractor landscape is presented.

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Lyman, C. A., Richman, S., Morris, M. C., Cao, H., Scerri, A., Cheadle, C., Broderick, G.. 2021-11-11. Attractor Landscapes as a Model Selection Criterion in Data Poor Environments. https://doi.org/10.1101/2021.11.09.466986

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