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bioRxiv · 10.1101/2021.11.02.466896

Influence of Response Criterion on Nociceptive Detection Thresholds and Evoked Potentials

van den Berg, B.·Vanwinsen, L.·Pezzali, G.·Buitenweg, J. R.
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Abstract

Pain scientists and clinicians search for objective measures of altered nociceptive processing to study and stratify chronic pain patients. Nociceptive processing can be studied by observing a combination of nociceptive detection thresholds and evoked potentials. However, it is unknown whether the nociceptive detection threshold measured using a Go-/No-Go (GN) procedure can be biased by a response criterion. In this study, we compared nociceptive detection thresholds, psychometric slopes and central evoked potentials obtained during a GN procedure with those obtained during a 2-interval forced choice (2IFC) procedure to determine 1) if the nociceptive detection threshold during a GN procedure is biased by a criterion and 2) to determine if nociceptive evoked potentials observed in response to stimuli around the detection threshold are biased by a criterion. We found that the detection threshold can be higher when assessed using a GN procedure in comparison with the 2IFC procedure. The average P2 component in the central evoked potential showed on-off behavior with respect to stimulus detection and increased proportionally with the detection probability during a GN procedure. These data suggest that nociceptive detection thresholds estimated using a GN procedure are subject to a response criterion.

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van den Berg, B., Vanwinsen, L., Pezzali, G., Buitenweg, J. R.. 2021-11-04. Influence of Response Criterion on Nociceptive Detection Thresholds and Evoked Potentials. https://doi.org/10.1101/2021.11.02.466896

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