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bioRxiv · 10.1101/2021.10.25.465685

Perception of a conserved family of plant signalling peptides by the receptor kinase HSL3

Rhodes, J.·Roman, A.-O.·Bjornson, M.·Brandt, B.·Derbyshire, P.·Wyler, M.·Schmid, M.·Menke, F. L.·Santiago, J.·Zipfel, C.
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Abstract

Plant genomes encode hundreds of secreted peptides; however, relatively few have been characterised. We report here an uncharacterised, stress-induced family of plant signalling peptides, which we call CTNIPs. Based on the role of the common co-receptor BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED KINASE 1 (BAK1) in CTNIP-induced responses, we identified the orphan receptor kinase HAESA-LIKE 3 (HSL3) as the CTNIP receptor via a proteomics approach. CTNIP binding, ligand-triggered complex formation with BAK1, and induced downstream responses all involve HSL3. Notably, the HSL3-CTNIP signalling module is evolutionarily ancient, predating the divergence of extant angiosperms. The identification of this signalling module will help establish its physiological role and provides a resource to understand further receptor-ligand co-evolution.

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Rhodes, J., Roman, A.-O., Bjornson, M., Brandt, B., Derbyshire, P., Wyler, M., Schmid, M., Menke, F. L., Santiago, J., Zipfel, C.. 2021-10-26. Perception of a conserved family of plant signalling peptides by the receptor kinase HSL3. https://doi.org/10.1101/2021.10.25.465685

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