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bioRxiv · 10.1101/2021.10.19.465016

Cortico-Subcortical Interactions in Overlapping Communities of Edge Functional Connectivity

Abstract

Both cortical and subcortical regions can be functionally organized into networks. Regions of the basal ganglia are extensively interconnected with the cortex via reciprocal connections that relay and modulate cortical function. Here we employ an edge-centric approach, which computes co-fluctuations among region pairs in a network to investigate the role and interaction of subcortical regions with cortical systems. By clustering edges into communities, we show that cortical systems and subcortical regions couple via multiple edge communities, with hippocampus and amygdala having a distinct pattern from striatum and thalamus. We show that the edge community structure of cortical networks is highly similar to one obtained from cortical nodes when the subcortex is present in the network. Additionally, we show that the edge community profile of both cortical and subcortical nodes can be estimates solely from cortico-subcortical interactions. Finally, we used a motif analysis focusing on edge community triads where a subcortical region coupled to two cortical regions and found that two community triads where one community couples the subcortex to the cortex were overrepresented. In summary, our results show organized coupling of the subcortex to the cortex that may play a role in cortical organization of primary sensorimotor/attention and heteromodal systems and puts forth the motif analysis of edge community triads as a promising method for investigation of communication patterns in networks.

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BibTeXRIS

Chumin, E. J., Faskowitz, J., Zamani Esfahlani, F., Jo, Y., Merritt, H. L., Tanner, J. C., Cutts, S. A., Pope, M. E., Sporns, O., Betzel, R.. 2021-10-20. Cortico-Subcortical Interactions in Overlapping Communities of Edge Functional Connectivity. https://doi.org/10.1101/2021.10.19.465016

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