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bioRxiv · 10.1101/2021.10.07.463171

Transcriptional differences of lipid-metabolizing enzymes in sebocytes derived from sebaceous glands of the skin and pre-putial glands

Abstract

Sebaceous glands are adnexal structures, which critically contribute to skin homeostasis and the establishment of a functional epidermal barrier. Sebocytes, the main cell population found within the sebaceous glands, are highly specialized lipid-producing cells. Sebaceous gland-resembling tissue structures are also found in male rodents in form of preputial glands. Similar to sebaceous glands, they are composed of lipid-specialized sebocytes. Due to a lack of adequate organ culture models for skin sebaceous glands and the fact that preputial glands are much larger and easier to handle, previous studies have used preputial glands as a model for skin sebaceous glands. Here, we compared both types of sebocytes, using a single cell RNA sequencing approach, to unravel potential similarities and differences between the two sebocyte populations. In spite of common gene expression patterns due to general lipid-producing properties, we found significant differences in the expression levels of genes encoding enzymes involved in the biogenesis of specialized lipid classes. Specifically, genes critically involved in the mevalonate pathway, including squalene synthase, as well as the sphingolipid salvage pathway, such as ceramide synthase, (acid) sphingomyelinase or acid and alkaline ceramidases, were significantly less expressed by preputial gland sebocytes. Together, our data revealed tissue-specific sebocyte populations, indicating major developmental, functional as well as biosynthetic differences between both glands. The use of preputial glands as surrogate model to study skin sebaceous glands is therefore limited, and major differences between both glands need to be carefully considered before planning an experiment.

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BibTeXRIS

Klas, K., Copic, D., Direder, M., Laggner, M., Prucksamas, P. S., Gruber, F., Ankersmit, H. J., Mildner, M.. 2021-10-07. Transcriptional differences of lipid-metabolizing enzymes in sebocytes derived from sebaceous glands of the skin and pre-putial glands. https://doi.org/10.1101/2021.10.07.463171

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