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bioRxiv · 10.1101/2021.10.06.462889

Mapping the functional interactions at the tumor-immune checkpoint interface

Bozorgui, B.·Kong, E. K.·Luna, A.·Korkut, A.
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Abstract

It is challenging to identify the tumor-immune system interactions that modulate immune states and immunotherapy responses due to the prohibitively complex space of possible interactions. Our statistical analysis framework, ImogiMap quantifies tumor-immune interactions based on their synergistic co-associations with immune-associated phenotypes. ImogiMap-based analyses recapitulated known interactions modulating immunotherapy responses and nominated the CD86/CD70 axis as an immunotherapy target that overlaps with IFNG overexpression and patient survival in endometrial carcinoma.

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Bozorgui, B., Kong, E. K., Luna, A., Korkut, A.. 2021-10-07. Mapping the functional interactions at the tumor-immune checkpoint interface. https://doi.org/10.1101/2021.10.06.462889

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