Neural networks implicated in autobiographical memory training

Cirneci, D.; Onu, M.; Papasteri, C. C.; Georgescu, D. P.; Poalelungi, C.; Sofonea, A.; Puscasu, N.; Podina, I. R.; Berceanu, A. I.; Carcea, I.

doi:10.1101/2021.10.05.463255

bioRxiv · 10.1101/2021.10.05.463255

Neural networks implicated in autobiographical memory training

Cirneci, D.·Onu, M.·Papasteri, C. C.·Georgescu, D. P.·Poalelungi, C.·Sofonea, A.·Puscasu, N.·Podina, I. R.·Berceanu, A. I.·Carcea, I.

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Abstract

Training of autobiographical memory has been proposed as intervention to improve cognitive functions. The neural substrates for such improvements are poorly understood. Several brain networks have been previously linked to autobiographical recollections, including the default mode network (DMN) and the sensorimotor network. Here we tested the hypothesis that different neural networks support distinct aspects of memory improvement in response to training on a group of 59 subjects. We found that memory training increases DMN connectivity, and this associates with improved recollection of cue-specific memories. On the contrary, training decreased connectivity in the sensorimotor network, a decrease that correlated with improved ability for voluntary recall. Moreover, only decreased sensorimotor connectivity associated with training-induced decrease in the TNF immunological factor, which has been previously linked to improved cognitive performance. We identified functional and biochemical factors that associate with distinct memory processes improved by autobiographical training. Pathways which connect autobiographical memory to both high level cognition and somatic physiology are discussed.

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Cirneci, D., Onu, M., Papasteri, C. C., Georgescu, D. P., Poalelungi, C., Sofonea, A., Puscasu, N., Podina, I. R., Berceanu, A. I., Carcea, I.. 2021-10-07. Neural networks implicated in autobiographical memory training. https://doi.org/10.1101/2021.10.05.463255

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