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bioRxiv · 10.1101/2021.09.23.461551

Vertex-wise characterization of Non-Human Primate cortical development with prenatal insights.

Abstract

Characterization of the interwoven complexities of early cortical thickness development has been an ongoing undertaking in neuroscience research. Longitudinal studies of Non-Human Primates (NHP) offer unique advantages to categorizing the diverse patterns of cortical growth trajectories. Here, we used latent growth models to characterize the trajectories of typical cortical thickness development in Japanese macaques at each cortical surface vertex (i.e. grayordinate). Cortical thickness from 4 to 36 months showed regional specific linear and non-linear trajectories and distinct maturation timing across the cortex. Intriguingly, we revealed a "accumulation/ablation phenomenon" of cortical maturation where the most profound development changes in cortical thickness occur in the accumulation or ablation zones surrounding the focal points (i.e., a center of a delineated regions where cortical thickness is thickest or thinnest) throughout the brain. We further examined maternal diet and inflammation in the context of these typical brain trajectories and known network architecture. A well-controlled NHP model of a maternal "Western-style" diet was used alongside measures of inflammatory cytokine interleukin-6 (IL-6) in the mothers during gestation. We observed that these accumulation and ablation zones of variable change might be most susceptible to environmental effects. The maternal factors, diet and inflammation during pregnancy were distinctively associated with different aspects of offspring cortical development reflected in regions related to distinctive functional networks. Our findings characterize the versatile intricacies of typical cortical thickness development and highlight how the maternal environment plays a role in offspring cortical development.

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BibTeXRIS

Ramirez, J. S. B., Hermosillo, R., Thomas, E., Zhu, J. Y., Sturgeon, D., Schifsky, E., Galassi, A., Thompson, J. R., Bagley, J. L., Milham, M. P., Miranda-Dominguez, O., Papadakis, S., Bah, M., Mitchell, A., Xu, T., Graham, A. M., Feczko, E., Sullivan, E. L., Fair, D. A.. 2021-09-24. Vertex-wise characterization of Non-Human Primate cortical development with prenatal insights.. https://doi.org/10.1101/2021.09.23.461551

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