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bioRxiv · 10.1101/2021.09.01.458601

Neural Excursions from Low-Dimensional Manifold Structure Explain Intersubject Variation in Human Motor Learning

Abstract

Humans vary greatly in their motor learning abilities, yet little is known about the neural mechanisms that underlie this variability. Recent neuroimaging and electrophysiological studies demonstrate that large-scale neural dynamics inhabit a low-dimensional subspace or manifold, and that learning is constrained by this intrinsic manifold architecture. Here we asked, using functional MRI, whether subject-level differences in neural excursion from manifold structure can explain differences in learning across participants. We had subjects perform a sensorimotor adaptation task in the MRI scanner on two consecutive days, allowing us to assess their learning performance across days, as well as continuously measure brain activity. We find that the overall neural excursion from manifold activity in both cognitive and sensorimotor brain networks is associated with differences in subjects patterns of learning and relearning across days. These findings suggest that off-manifold activity provides an index of the relative engagement of different neural systems during learning, and that intersubject differences in patterns of learning and relearning across days are related to reconfiguration processes in cognitive and sensorimotor networks during learning.

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BibTeXRIS

Areshenkoff, C. N., Gale, D. J., Nashed, J. Y., Standage, D., Flanagan, J. R., Gallivan, J.. 2021-09-03. Neural Excursions from Low-Dimensional Manifold Structure Explain Intersubject Variation in Human Motor Learning. https://doi.org/10.1101/2021.09.01.458601

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