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bioRxiv · 10.1101/2021.09.01.458493

Pre- and postsynaptically expressed spike-timing-dependent plasticity contribute differentially to neuronal learning

Abstract

A plethora of experimental studies have shown that long-term synaptic plasticity can be expressed pre- or postsynaptically depending on a range of factors such as developmental stage, synapse type, and activity patterns. The functional consequences of this diversity are not clear, although it is understood that whereas postsynaptic expression of plasticity predominantly affects synaptic response amplitude, presynaptic expression alters both synaptic response amplitude and short-term dynamics. In most models of neuronal learning, long-term synaptic plasticity is implemented as changes in connective weights. The consideration of long-term plasticity as a fixed change in amplitude corresponds more closely to post-than to presynaptic expression, which means theoretical outcomes based on this choice of implementation may have a postsynaptic bias. To explore the functional implications of the diversity of expression of long-term synaptic plasticity, we adapted a model of long-term plasticity, more specifically spike-timing-dependent plasticity (STDP), such that it was expressed either independently pre- or postsynaptically, or in a mixture of both ways. We compared pair-based standard STDP models and a biologically tuned triplet STDP model, and investigated the outcomes in a minimal setting, using two different learning schemes: in the first, inputs were triggered at different latencies, and in the second a subset of inputs were temporally correlated. We found that presynaptic changes adjusted the speed of learning, while postsynaptic expression was more efficient at regulating spike timing and frequency. When combining both expression loci, postsynaptic changes amplified the response range, while presynaptic plasticity allowed control over postsynaptic firing rates, potentially providing a form of activity homeostasis. Our findings highlight how the seemingly innocuous choice of implementing synaptic plasticity by single weight modification may unwittingly introduce a postsynaptic bias in modelling outcomes. We conclude that pre- and postsynaptically expressed plasticity are not interchangeable, but enable complimentary functions. Author summaryDifferences between functional properties of pre- or postsynaptically expressed long-term plasticity have not yet been explored in much detail. In this paper, we used minimalist models of STDP with different expression loci, in search of fundamental functional consequences. Biologically, presynaptic expression acts mostly on neurotransmitter release, thereby altering short-term synaptic dynamics, whereas postsynaptic expression affects mainly synaptic gain. We compared models where plasticity was expressed only presynaptically or postsynaptically, or in both ways. We found that postsynaptic plasticity had a bigger impact over response times, while both pre- and postsynaptic plasticity were similarly capable of detecting correlated inputs. A model with biologically tuned expression of plasticity also completed these tasks over a range of frequencies. Also, postsynaptic spiking frequency was not directly affected by presynaptic plasticity of short-term plasticity alone, however in combination with a postsynaptic component, it helped restrain positive feedback, contributing to activity homeostasis. In conclusion, expression locus may determine affinity for distinct coding schemes while also contributing to keep activity within bounds. Our findings highlight the importance of carefully implementing expression of plasticity in biological modelling, since the locus of expression may affect functional outcomes in simulations.

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BibTeXRIS

Mizusaki, B. E. P., Li, S. S. Y., Costa, R. P., Sjöström, J.. 2021-09-01. Pre- and postsynaptically expressed spike-timing-dependent plasticity contribute differentially to neuronal learning. https://doi.org/10.1101/2021.09.01.458493

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