A novel analytical decoder of BOLD signals for dissociating latent neurobehavioral processes

Abstract

How to retrieve latent neurobehavioral processes from complex neurobiological signals is an important yet unresolved challenge. Here, we develop a novel approach, orthogonal-Decoding multi-Cognitive Processes (DeCoP), to reveal underlying latent neurobehavioral processing and show that its performance is superior to traditional non-orthogonal decoding in terms of both false inference and robustness. Processing value and salience information are two fundamental but mutually confounded pathways of reward reinforcement essential for decision making. During reward/punishment anticipation, we applied DeCoP to decode brain-wide responses into spatially overlapping, yet functionally independent, evaluation and readiness processes, which are modulated differentially by meso-limbic vs nigro-striatal dopamine systems. Using DeCoP, we further demonstrated that most brain regions only encoded abstract information but not the exact input, except for dACC and insula. Furthermore, our novel analytical principle could be applied generally to decode multiple latent neurobehavioral processes and thus advance both the design and hypothesis testing for cognitive tasks.