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bioRxiv · 10.1101/2021.08.14.456353

Cutting epitopes to survive: the case of lambda variant

Pascarella, S.·Ciccozzi, M.·Bianchi, M.·Benvenuto, D.·Cauda, R.·Cassone, A.
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Abstract

This manuscript concisely reports an in-silico study on the potential impact of the Spike protein mutations on immuno-escape ability of SARS-CoV-2 lambda variant. Biophysical and bioinformatics data suggest that a combination of shortening immunogenic epitope loops and generation of potential N-glycosylation sites may be a viable adaptation strategy potentially allowing this emerging viral variant escaping host immunity.

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Pascarella, S., Ciccozzi, M., Bianchi, M., Benvenuto, D., Cauda, R., Cassone, A.. 2021-08-16. Cutting epitopes to survive: the case of lambda variant. https://doi.org/10.1101/2021.08.14.456353

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