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bioRxiv · 10.1101/2021.08.11.456012

In vitro determination of inhibitory effects by humic substances complexing Zn and Se on SARS-CoV-2 virus replication

Palyi, B.·Kis, Z.·Hajdrik, P.·Kovacs, N. S.·Veres, D. S.·Szigeti, K.·Hegedus, I.·Kovacs, T. J.·Bergmann, R. K.·Mathe, D.
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Abstract

Humic substances are well known human nutritional supplement materials and play important performance-enhancing roles as animal feed additives, too. For decades, ingredients of humic substances have also been proven to carry potent antiviral effects against different viruses. Here, the antiviral activity of a humic substance containing ascorbic acid, Se- and Zn2+ ions intended as a nutritional supplement material was investigated against SARS-CoV-2 virus B1.1.7 Variant of Concern ("Alpha Variant") in a VeroE6 cell line. Results show that this combination has a significant in vitro antiviral effect at a very low concentration range of its intended active ingredients. Even picomolar concentration ranges of humic substances, vitamin C and Zn/Se ions in the given composition were enough to achieve fifty percent viral replication inhibition in the applied SARS-CoV-2 virus inhibition test.

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Palyi, B., Kis, Z., Hajdrik, P., Kovacs, N. S., Veres, D. S., Szigeti, K., Hegedus, I., Kovacs, T. J., Bergmann, R. K., Mathe, D.. 2021-08-12. In vitro determination of inhibitory effects by humic substances complexing Zn and Se on SARS-CoV-2 virus replication. https://doi.org/10.1101/2021.08.11.456012

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