Distributed Patterns of Functional Connectivity Underlie Individual Differences in Long-Term Memory Forgetting

Abstract

Despite the importance of memories in everyday life and the progress made in understanding how they are encoded and retrieved, the neural processes by which declarative memories are maintained or forgotten remain elusive. Part of the problem is that it is empirically difficult to measure the rate at which memories fade, even between repeated presentations of the source of the memory. Without such a ground-truth measure, it is hard to identify the corresponding neural correlates. This study addresses this problem by comparing individual patterns of functional connectivity against behavioral differences in forgetting speed derived from computational phenotyping. Specifically, the individual-specific values of the speed of forgetting in long-term memory (LTM) were estimated for 33 participants using a formal model fit to accuracy and response time data from an adaptive paired-associate learning task. Individual speeds of forgetting were then used to examine participant-specific patterns of resting-state fMRI connectivity, using machine learning techniques to identify the most predictive and generalizable features. Our results show that individual speeds of forgetting are associated with resting-state connectivity within the default mode network (DMN) as well as between the DMN and cortical sensory areas. Cross-validation showed that individual speeds of forgetting were predicted with high accuracy (r = .78) from these connectivity patterns alone. These results support the view that DMN activity and the associated sensory regions are actively involved in maintaining memories and preventing their decline, a view that can be seen as evidence for the hypothesis that forgetting is a result of storage degradation, rather than of retrieval failure. Author SummaryWhy do some people forget faster than others? This study investigates individual differences in long-term memory forgetting by linking them to patterns of brain connectivity. Although memory formation and retrieval are well-studied, much less is known about the brain processes that determine how memories are maintained or lost over time. A major challenge has been accurately measuring forgetting. To address this, we used an innovative method: fitting a computational model of memory to each participants accuracy and response time data during a learning task. This allowed us to estimate each persons unique rate of forgetting. We then examined how these rates related to resting-state brain connectivity. The results revealed that individual forgetting speeds were strongly associated with connectivity between the brains default mode network (DMN) and cortical sensory regions--areas thought to support long-term memory maintenance. These findings suggest that forgetting reflects how well memory traces are preserved in the brain, not just whether they can be retrieved.