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bioRxiv · 10.1101/2021.07.30.454314

Scaffold modelling captures the structure-function-dynamics relationship in brain microcircuits

De Schepper, R. G.·Geminiani, A.·Masoli, S.·Rizza, M. F.·Antonietti, A.·Casellato, C.·D'Angelo, E. U.
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Abstract

1Modelling brain networks with complex configuration and cellular properties requires a set of neuroinformatic tools and an organized staged workflow. We have therefore developed the Brain Scaffold Builder (BSB), a new modeling framework embedding multiple strategies for cell placement and connectivity and a flexible management of cellular and network mechanisms. With BSB, for the first time, the mouse cerebellar cortex was reconstructed and simulated at cellular resolution, using morphologically realistic multi-compartmental single-neuron models. Embedded connection rules allowed BSB to generate the cerebellar connectome, unifying a collection of scattered experimental data into a coherent construct. Naturalistic background and sensory-burst stimulation were used for functional validation against recordings in vivo, monitoring the impact of subcellular mechanisms on signal propagation and spatio-temporal processing and providing a new ground-truth about circuit organization for the prediction of neural dynamics.

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De Schepper, R. G., Geminiani, A., Masoli, S., Rizza, M. F., Antonietti, A., Casellato, C., D'Angelo, E. U.. 2021-08-01. Scaffold modelling captures the structure-function-dynamics relationship in brain microcircuits. https://doi.org/10.1101/2021.07.30.454314

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