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bioRxiv · 10.1101/2021.07.29.454329

An Oscillatory Mechanism for Multi-level Storage in Short-term Memory

Abstract

Oscillatory activity is commonly observed during the maintenance of information in short-term memory, but its role remains unclear. Non-oscillatory models of short-term memory storage are able to encode stimulus identity through their spatial patterns of activity, but are typically limited to either an all-or-none representation of stimulus amplitude or exhibit a biologically implausible exact-tuning condition. Here, we demonstrate a simple phase-locking mechanism by which oscillatory input enables a circuit to generate persistent or sequential activity patterns that encode information not only in their location but also in their discretely graded amplitudes. SignificanceA core observation in many memory systems and tasks is the presence of oscillations during memory maintenance. Here, we demonstrate a mechanism for the accumulation and storage of information in short-term memory in which oscillatory activity enables a solution to long-standing challenges in modeling the persistent neural activity underlying working memory. These challenges include the ability to encode information with low firing rates, multi-level storage of stimulus amplitude without extreme fine tuning, and multi-level storage of information in sequential activity. Altogether, this work proposes a new class of models for the storage of information in working memory, a new potential role for brain oscillations, and a novel dynamical mechanism for multi-stability.

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BibTeXRIS

Champion, K., Gozel, O., Lankow, B., Ermentrout, B., Goldman, M.. 2021-07-30. An Oscillatory Mechanism for Multi-level Storage in Short-term Memory. https://doi.org/10.1101/2021.07.29.454329

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