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bioRxiv · 10.1101/2021.07.21.453255

Fast and accurate bootstrap confidence limits on genome-scale phylogenies using little bootstraps

Sharma, S.·Kumar, S.
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Abstract

Felsensteins bootstrap resampling approach, applied in thousands of research articles, imposes a high computational burden for very long sequence alignments. We show that the bootstrapping of a collection of little subsamples, coupled with median bagging of subsample confidence limits, produces accurate bootstrap confidence for phylogenetic relationships in a fraction of time and memory. The little bootstraps approach will enhance rigor, efficiency, and parallelization of big data phylogenomic analyses.

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Sharma, S., Kumar, S.. 2021-07-23. Fast and accurate bootstrap confidence limits on genome-scale phylogenies using little bootstraps. https://doi.org/10.1101/2021.07.21.453255

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