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bioRxiv · 10.1101/2021.07.21.453225

Conserved Circuits for Direction Selectivity in the Primate Retina

Abstract

The detection of motion direction is a fundamental visual function and a classic model for neural computation1,2. In the non-primate mammalian retina, direction selectivity arises in starburst amacrine cell (SAC) dendrites, which provide selective inhibition to ON and ON-OFF direction selective retinal ganglion cells (dsRGCs)3,4. While SACs are present in primates5, their connectivity is unknown and the existence of primate dsRGCs remains an open question. Here we present a connectomic reconstruction of the primate ON SAC circuit from a serial electron microscopy volume of macaque central retina. We show that the structural basis for the SACs ability to compute and confer directional selectivity on post-synaptic RGCs6 is conserved in primates and that SACs selectively target a single ganglion cell type, a candidate homolog to the mammalian ON-sustained dsRGCs that project to the accessory optic system and contribute to gaze-stabilizing reflexes7,8. These results indicate that the capacity to compute motion direction is present in the retina, far earlier in the primate visual system than classically thought, and they shed light on the distinguishing features of primate motion processing by revealing the extent to which ancestral motion circuits are conserved.

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Patterson, S. S., Bembry, B. N., Mazzaferri, M. A., Neitz, M., Rieke, F., Soetedjo, R., Neitz, J.. 2021-07-22. Conserved Circuits for Direction Selectivity in the Primate Retina. https://doi.org/10.1101/2021.07.21.453225

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