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bioRxiv · 10.1101/2021.07.08.451426

Antibody and T cell memory immune response after two doses of the BNT162b2 mRNA vaccine in older adults with and without prior SARS-CoV-2 infection

Demaret, J.·Corroyer-Simovic, B.·Alidjinou, E. K.·Goffard, A.·Trauet, J.·Miczek, S.·Vuotto, F.·Dendooven, A.·Huvent-Grelle, D.·Podvin, J.·Dreuil, D.·Faure, K.·Deplanque, D.·Bocket, L.·Duhamel, A.·Labreuche, J.·Sobaszek, A.·Puisieux, F.·Labalette, M.·Lefevre, G.
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Abstract

We quantified S1-specific IgG, neutralizing antibody titers, specific IFN{gamma} secreting T cells and functionality of specific CD4+ and CD8+ T cells in 130 young adults (median age 44.0 years) and 106 older residents living in a long-term care facility (86.5 years) after 2 doses of BNT162b2. Three months after the first injection, humoral and cellular memory responses were dramatically impaired in the 54 COVID-19-naive older compared to the 121 COVID-19-naive younger adults. Notably, older participants neutralizing antibodies, detected in 76.5% (versus 100% in young adults, P < 0.0001), were ten times lower than the youngers antibody titers (P < 0.0001). Antibody and T cell responses were greater among the 52 COVID-19-recovered than among the 54 COVID-19-naive older adults (P < 0.0001). Our study shows that 2 doses of BNT162b2 does not guarantee long-term protection against SARS-CoV-2 in the older. An additional dose should be considered to boost their specific memory response.

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Demaret, J., Corroyer-Simovic, B., Alidjinou, E. K., Goffard, A., Trauet, J., Miczek, S., Vuotto, F., Dendooven, A., Huvent-Grelle, D., Podvin, J., Dreuil, D., Faure, K., Deplanque, D., Bocket, L., Duhamel, A., Labreuche, J., Sobaszek, A., Puisieux, F., Labalette, M., Lefevre, G.. 2021-07-08. Antibody and T cell memory immune response after two doses of the BNT162b2 mRNA vaccine in older adults with and without prior SARS-CoV-2 infection. https://doi.org/10.1101/2021.07.08.451426

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