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bioRxiv · 10.1101/2021.06.21.449154

The Digital Brain Bank: an open access platform for post-mortem datasets

Abstract

Post-mortem MRI provides the opportunity to acquire high-resolution datasets to investigate neuroanatomy, and validate the origins of image contrast through microscopy comparisons. We introduce the Digital Brain Bank (open.win.ox.ac.uk/DigitalBrainBank), a data release platform providing open access to curated, multimodal post-mortem neuroimaging datasets. Datasets span three themes - Digital Neuroanatomist: datasets for detailed neuroanatomical investigations; Digital Brain Zoo: datasets for comparative neuroanatomy; Digital Pathologist: datasets for neuropathology investigations. The first Digital Brain Bank release includes twenty one distinctive whole-brain diffusion MRI datasets for structural connectivity investigations, alongside microscopy and complementary MRI modalities. This includes one of the highest-resolution whole-brain human diffusion MRI datasets ever acquired, whole-brain diffusion MRI in fourteen non-human primate species, and one of the largest post-mortem whole-brain cohort imaging studies in neurodegeneration. The Digital Brain Bank is the culmination of our labs investment into post-mortem MRI methodology and MRI-microscopy analysis techniques. This manuscript provides a detailed overview of our work with post-mortem imaging to date, including the development of diffusion MRI methods to image large post-mortem samples, including whole, human brains. Taken together, the Digital Brain Bank provides crossscale, cross-species datasets facilitating the incorporation of post-mortem data into neuroimaging studies.

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BibTeXRIS

Tendler, B. C., Hanayik, T., Ansorge, O., Bangerter-Christensen, S., Berns, G. S., Bertelsen, M. F., Bryant, K. L., Foxley, S., Howard, A. F. D., Huszar, I., Khrapitchev, A. A., Leonte, A., Manger, P. R., Menke, R. A. L., Mollink, J., Mortimer, D., Pallebage-Gamarallage, M., Roumazeilles, L., Sallet, J., Scott, C., Smart, A., Turner, M. R., Wang, C., Jbabdi, S., Mars, R. B., Miller, K. L.. 2021-06-22. The Digital Brain Bank: an open access platform for post-mortem datasets. https://doi.org/10.1101/2021.06.21.449154

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