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bioRxiv · 10.1101/2021.06.15.448591

Vision is required for the formation of binocular neurons prior to the classical critical period

Abstract

Depth perception emerges from the development of binocular neurons in primary visual cortex. Vision is required for these neurons to acquire their mature responses to visual stimuli. The prevailing view is that vision does not influence binocular circuitry until the onset of the critical period, about a week after eye opening, and that plasticity of visual responses is triggered by increased inhibition. Here, we show that vision is required to form binocular neurons and to improve binocular tuning and matching from eye opening until critical period closure. Enhancing inhibition does not accelerate this process. Vision soon after eye opening improves the tuning properties of binocular neurons by strengthening and sharpening ipsilateral-eye cortical responses. This progressively changes the population of neurons in the binocular pool and this plasticity is sensitive to interocular differences prior to critical period onset. Thus, vision establishes binocular circuitry and guides binocular plasticity from eye opening.

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BibTeXRIS

Tan, L., Ringach, D. L., Zipursky, S. L., Trachtenberg, J. T.. 2021-06-16. Vision is required for the formation of binocular neurons prior to the classical critical period. https://doi.org/10.1101/2021.06.15.448591

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