Action inhibition revisited: a new method identifiescompromised reactive but intact proactive control inTourette disorder

Indrajeet, I.; Atkinson-Clement, C.; Worbe, Y.; Pouget, P.; Ray, S.

doi:10.1101/2021.06.15.448397

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bioRxiv · 10.1101/2021.06.15.448397

Action inhibition revisited: a new method identifiescompromised reactive but intact proactive control inTourette disorder

Indrajeet, I.·Atkinson-Clement, C.·Worbe, Y.·Pouget, P.·Ray, S.

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Abstract

Tourette disorder (TD) is characterized by tics, which are sudden repetitive involuntary movements or vocalizations. Deficits in inhibitory control in TD patients remain inconclusive from the traditional method of estimating the ability to stop an impending action, which requires careful interpretation of a parameter derived from race model. One possible explanation for these inconsistencies is that race models assumptions are often violated. Here, we used a pair of metrics derived from a recent alternative model to address why stopping performance in TD patients is unaffected by impairments in neural circuitry. These new metrics distinguish between proactive and reactive inhibitory control and estimate them separately. When these metrics were contrasted with healthy controls (HC), we identified robust deficits in reactive control in TD patients, but not in proactive control. The patient population exhibited difficulty in slowing down the speed of movement planning, which they compensated by their intact ability of procrastination. TEASERTourette disorder patients inhibit action by means of strategic postponement to compensate impaired slowness in preparation.

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Indrajeet, I., Atkinson-Clement, C., Worbe, Y., Pouget, P., Ray, S.. 2021-06-15. Action inhibition revisited: a new method identifiescompromised reactive but intact proactive control inTourette disorder. https://doi.org/10.1101/2021.06.15.448397

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