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bioRxiv · 10.1101/2021.06.11.448146

Cell entry inhibitor with sulfonated colloid gold as new potent broad-spectrum virucides

Chin, C.
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Abstract

We recently developed nontoxic, broad-spectrum virucidal gold nanoparticles, less than 10nm sized, modified with sulfonic acids (mesilate) that mimic heparan sulfates.Camostat, a serine protease inhibitor can introduce gold nanoparticles to the influenza virus via ionic bonds.In this study, we examined the ability of a novel sulfonated colloid gold to inhibit the virus in vivo. Thus, camostat-colloid gold is a promising candidate for the development of antiviral drugs to prevent and treat influenza infection.

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Chin, C.. 2021-06-12. Cell entry inhibitor with sulfonated colloid gold as new potent broad-spectrum virucides. https://doi.org/10.1101/2021.06.11.448146

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