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bioRxiv · 10.1101/2021.06.11.448038

Effect of levodopa on human brain connectome in Parkinsons disease

Farashi, S.·Khazaei, M.
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Abstract

ObjectiveLevodopa-based drugs are widely used for mitigating the complications induced by PD. Despite the positive effects, several issues regarding the way that levodopa changes brain activities have remained unclear. MethodsA combined strategy using EEG data and graph theory was used for investigating how levodopa changed connectome and processing hubs of the brain during resting-state. Obtained results were subjected to ANOVA test and multiple-comparison post-hoc correction procedure. ResultsResults showed that graph topology of PD patients was not significantly different with the healthy group during eyes-closed condition while in eyes-open condition statistical significant differences were found. The main effect of levodopa medication was observed for gamma-band activity of the brain in which levodopa changed the brain connectome toward a star-like topology. Considering the beta subband of EEG data, graph leaf number increased following levodopa medication in PD patients. Enhanced brain connectivity in gamma band and reduced beta band connections in basal ganglia were also observed after levodopa medication. Furthermore, source localization using dipole fitting showed that levodopa prescription suppressed the activity of collateral trigone. ConclusionOur combined EEG and graph analysis showed that levodopa medication changed the brain connectome, especially in the high-frequency range of EEG (beta and gamma). HighlightsO_LINo differences were found between graph features between ON and OFF PD cases in eyes-closed. C_LIO_LILevodopa enhanced connectivity in gamma band in PD patients. C_LIO_LILevodopa inhibited brain connectivity in beta band. C_LI

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Farashi, S., Khazaei, M.. 2021-06-11. Effect of levodopa on human brain connectome in Parkinsons disease. https://doi.org/10.1101/2021.06.11.448038

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