Consciousness is supported by near-critical cortical electrodynamics

Toker, D.; Pappas, I.; Lendner, J. D.; Frohlich, J.; Mateos, D. M.; Muthukumaraswamy, S.; Carhart-Harris, R.; Paff, M.; Vespa, P. M.; Monti, M. M.; Sommer, F. T.; Knight, R. T.; D'Esposito, M.

doi:10.1101/2021.06.10.447959

bioRxiv · 10.1101/2021.06.10.447959

Consciousness is supported by near-critical cortical electrodynamics

Toker, D.·Pappas, I.·Lendner, J. D.·Frohlich, J.·Mateos, D. M.·Muthukumaraswamy, S.·Carhart-Harris, R.·Paff, M.·Vespa, P. M.·Monti, M. M.·Sommer, F. T.·Knight, R. T.·D'Esposito, M.

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Abstract

Mounting evidence suggests that during conscious states, the electrodynamics of the cortex are poised near a critical point or phase transition, and that this near-critical behavior supports the vast flow of information through cortical networks during conscious states. Here, for the first time, we empirically identify the specific critical point near which conscious cortical dynamics operate as the edge-of-chaos critical point, or the boundary between periodicity/stability and chaos/instability. We do so by applying the recently developed modified 0-1 chaos test to electrocorticography (ECoG) and magne-toencephalography (MEG) recordings from the cortices of humans and macaques across normal waking, generalized seizure, GABAergic anesthesia, and psychedelic states. Our evidence suggests that cortical information processing is disrupted during unconscious states because of a transition of cortical dynamics away from this critical point; conversely, we show that psychedelics may increase the information-richness of cortical activity by tuning cortical electrodynamics closer to this critical point. Finally, we analyze clinical electroencephalography (EEG) recordings from patients with disorders of consciousness (DOC), and show that assessing the proximity of cortical electrodynamics to the edge-of-chaos critical point may be clinically useful as a new biomarker of consciousness. Significance StatementWhat changes in the brain when we lose consciousness? One possibility is that the loss of consciousness corresponds to a transition of the brains electric activity away from edge-of-chaos criticality, or the knifes edge in between stability and chaos. Recent mathematical developments have produced novel tools for testing this hypothesis, which we apply for the first time to cortical recordings from diverse brain states. We show that the electric activity of the cortex is indeed poised near the boundary between stability and chaos during conscious states and transitions away from this boundary during unconsciousness, and that this transition disrupts cortical information processing.

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Toker, D., Pappas, I., Lendner, J. D., Frohlich, J., Mateos, D. M., Muthukumaraswamy, S., Carhart-Harris, R., Paff, M., Vespa, P. M., Monti, M. M., Sommer, F. T., Knight, R. T., D'Esposito, M.. 2021-06-11. Consciousness is supported by near-critical cortical electrodynamics. https://doi.org/10.1101/2021.06.10.447959

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