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bioRxiv · 10.1101/2021.06.09.447404

Transcriptomic similarities and differences between mouse models and human Alzheimer's Disease

De Bastiani, M. A.·Bellaver, B.·Collar, G.·Forner, S.·Martini, A. C.·Pascoal, T.·Zimmer, E.
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Abstract

Alzheimers disease (AD) is a multifactorial pathology, with most cases having a sporadic origin. Recently, knock-in (KI) models have been developed with the promise of resembling better sporadic human AD, such as the novel hA{beta}-KI mouse. Here, we compared hippocampal publicly available transcriptomic profiles of transgenic (5xFAD and APP/PS1) and KI (hA{beta}-KI) mouse models with early- (EOAD) and late- (LOAD) onset AD patients. Experimental validation of consistently dysregulated genes revealed four altered in mice (SLC11A1, S100A6, CD14, CD33, C1QB) and three in humans (S100A6, SLC11A1, KCNK). Additionally, the three mouse models presented more Gene Ontology biological processes terms and enriched signaling pathways in common with LOAD than with EOAD individuals. Finally, we identified 17 transcription factors potentially acting as master regulators of AD. Our cross-species analyses revealed that the three mouse models presented a remarkable similarity to LOAD, with the hA{beta}-KI being the more specific one.

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De Bastiani, M. A., Bellaver, B., Collar, G., Forner, S., Martini, A. C., Pascoal, T., Zimmer, E.. 2021-06-10. Transcriptomic similarities and differences between mouse models and human Alzheimer's Disease. https://doi.org/10.1101/2021.06.09.447404

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