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bioRxiv · 10.1101/2021.06.07.447464

Rat anterior cingulate cortex continuously signals decision variables in a patchforaging task

Abstract

In patch foraging tasks, animals must decide whether to remain with a depleting resource or to leave it in search of a potentially better source of reward. In such tasks, animals consistently follow the general predictions of optimal foraging theory (the Marginal Value Theorem; MVT): to leave a patch when the reward rate in the current patch depletes to the average reward rate across patches. Prior studies implicate an important role for the anterior cingulate cortex (ACC) in foraging decisions based on MVT: within single trials, ACC activity increases immediately preceding foraging decisions, and across trials, these dynamics are modulated as the value of staying in the patch depletes to the average reward rate. Here, we test whether these activity patterns reflect dynamic encoding of decision-variables and whether these signals are directly involved in decision-making. We developed a leaky accumulator model based on the MVT that generates estimates of decision variables within and across trials, and tested model predictions against ACC activity recorded from rats performing a patch foraging task. Model predicted changes in MVT decision variables closely matched rat ACC activity. Next, we pharmacologically inactivated ACC to test the contribution of these signals to decision-making. ACC inactivation had a profound effect on rats foraging decisions and response times yet rats still followed the MVT decision rule. These findings suggest that the ACC encodes foraging-related variables for reasons unrelated to patch-leaving decisions.

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BibTeXRIS

Kane, G. A., James, M. H., Shenhav, A., Daw, N. D., Cohen, J. D., Aston-Jones, G.. 2021-06-08. Rat anterior cingulate cortex continuously signals decision variables in a patchforaging task. https://doi.org/10.1101/2021.06.07.447464

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