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bioRxiv · 10.1101/2021.06.07.447234

Insulin is expressed by enteroendocrine cells during human fetal development

Egozi, A.·Llivichuzhca-Loja, D.·McCourt, B.·Farack, L.·An, X.·Wang, F.·Chen, K.·Konnikova, L.·Itzkovitz, S.
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Abstract

Generation of beta cells via transdifferentiation of other cell types is a promising avenue for the treatment of diabetes. Here, we reconstruct a single cell atlas of enteroendocrine cells in the human fetal and neonatal small intestine. We identify a subset of fetal enteroendocrine K/L cells that express high levels of insulin and other beta cell genes. Our findings highlight a potential extra-pancreatic source of beta cells and exposes its molecular blueprint.

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Egozi, A., Llivichuzhca-Loja, D., McCourt, B., Farack, L., An, X., Wang, F., Chen, K., Konnikova, L., Itzkovitz, S.. 2021-06-07. Insulin is expressed by enteroendocrine cells during human fetal development. https://doi.org/10.1101/2021.06.07.447234

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