Plasma-derived cell-free DNA methylomes might not enable detection and discrimination of intracranial tumors

Vitting-Seerup, K.

doi:10.1101/2021.06.02.446405

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bioRxiv · 10.1101/2021.06.02.446405

Plasma-derived cell-free DNA methylomes might not enable detection and discrimination of intracranial tumors

Vitting-Seerup, K.

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Abstract

Intracranial tumors are both hard to detect and diagnose, resulting in poor patient outcomes. For that reason, non-invasive methods enabling detection and discrimination of intracranial tumors have significant clinical potential. Recently Nassiri et al. propose plasma-derived cell-free DNA methylomes as such a method. Here I show that the results have been misinterpreted, and for many comparisons, no evidence supporting the conclusions are actually presented. While my analysis highlights the potential of plasma-derived cell-free DNA methylomes, the evidence provided by Nassiri et al. is simply currently insufficient.

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Vitting-Seerup, K.. 2021-06-02. Plasma-derived cell-free DNA methylomes might not enable detection and discrimination of intracranial tumors. https://doi.org/10.1101/2021.06.02.446405

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