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bioRxiv · 10.1101/2021.05.27.446002

Elevated colonic microbiota-associated paucimannosidic and truncated N-glycans in pediatric ulcerative colitis

Li, H.·Zhang, X.·Chen, R.·Cheng, K.·Ning, Z.·Li, J.·Twine, S.·Stintzi, A.·Mack, D.·Figeys, D.
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Abstract

Pediatric ulcerative colitis (UC) is a distinct type of inflammatory bowel disease with severe disease activity and rapid progression, which can lead to detrimental life-long consequences. The pathogenesis of pediatric UC remains unclear, although dysbiosis of the gut microbiota has been considered an important factor. In this study, we used mass spectrometry-based glycomic approaches to examine the N-glycans that were associated with the intestinal mucosal-luminal interface microbiota cells of treatment-naive pediatric UC or control patients. We observed abundant paucimannosidic and other truncated N-glycans that were associated with the microbiota and found that the pediatric UC microbiota samples contained significantly higher levels of these atypical N-glycans compared to those of controls. This study indicates that intestinal N-glycans may be used as novel UC biomarker candidates and the aberrant metabolism of glycans by gut microbiota may be involved in the pathogenesis of UC in children.

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Li, H., Zhang, X., Chen, R., Cheng, K., Ning, Z., Li, J., Twine, S., Stintzi, A., Mack, D., Figeys, D.. 2021-05-28. Elevated colonic microbiota-associated paucimannosidic and truncated N-glycans in pediatric ulcerative colitis. https://doi.org/10.1101/2021.05.27.446002

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