Dispersed Sleep Microstates and Associated Structural Changes in GBA1 Mouse: Relevance to Rapid Eye Movement Behavior Disorder

Gelegen, C.; Cash, D.; Ilic, K.; Sander, M.; Kim, E.; Simmons, C.; Bernanos, M.; Lamma, J.; Randall, K.; Brown, J.; Kalanj Bognar, S.; Cooke, S.; Chaudhury, K. R.; Ballard, C.; Francis, P.; Rosenzweig, I.

doi:10.1101/2021.05.26.445845

bioRxiv · 10.1101/2021.05.26.445845

Dispersed Sleep Microstates and Associated Structural Changes in GBA1 Mouse: Relevance to Rapid Eye Movement Behavior Disorder

Gelegen, C.·Cash, D.·Ilic, K.·Sander, M.·Kim, E.·Simmons, C.·Bernanos, M.·Lamma, J.·Randall, K.·Brown, J.·Kalanj Bognar, S.·Cooke, S.·Chaudhury, K. R.·Ballard, C.·Francis, P.·Rosenzweig, I.

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Abstract

Rapid eye movement (REM) sleep behaviour disorder (RBD) is a rare parasomnia that may predict the later occurrence of alpha-synucleinopathies. Variants in the gene encoding for the lysosomal enzyme glucocerebrosidase, GBA, strongly increase the risk of RBD. In a GBA1-mouse model recently shown to mimic prodromal stages of -synucleinopathy, we now demonstrate striking REM and NREM sleep abnormalities accompanied by distinct structural changes in the more widespread sleep neurocircuitry.

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Gelegen, C., Cash, D., Ilic, K., Sander, M., Kim, E., Simmons, C., Bernanos, M., Lamma, J., Randall, K., Brown, J., Kalanj Bognar, S., Cooke, S., Chaudhury, K. R., Ballard, C., Francis, P., Rosenzweig, I.. 2021-05-27. Dispersed Sleep Microstates and Associated Structural Changes in GBA1 Mouse: Relevance to Rapid Eye Movement Behavior Disorder. https://doi.org/10.1101/2021.05.26.445845

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