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bioRxiv · 10.1101/2021.05.25.445647

Diversity of satellite glia in sympathetic and sensory ganglia

Mapps, A.·Thomsen, M.·Boehm, E.·Zhao, H.·Hattar, S.·Kuruvilla, R.
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Abstract

Satellite glia are the major glial type found in ganglia of the peripheral nervous system and wrap around cell bodies of sympathetic and sensory neurons that are very diverse. Other than their close physical association with peripheral neurons, little is known about this glial population. Here, we performed single cell RNA sequencing analysis and identified five different populations of satellite glia from sympathetic and sensory ganglia. We identified three shared populations of satellite glia enriched in immune-response genes, immediate-early genes and ion channels/ECM-interactors, respectively. Sensory- and sympathetic-specific satellite glia are differentially enriched for modulators of lipid synthesis and metabolism. Sensory glia are also specifically enriched for genes involved in glutamate turnover. Further, satellite glia and Schwann cells can be distinguished by unique transcriptional signatures. This study reveals remarkable heterogeneity of satellite glia in the peripheral nervous system.

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Mapps, A., Thomsen, M., Boehm, E., Zhao, H., Hattar, S., Kuruvilla, R.. 2021-05-25. Diversity of satellite glia in sympathetic and sensory ganglia. https://doi.org/10.1101/2021.05.25.445647

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