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bioRxiv · 10.1101/2021.05.25.445617

Temporal Progression: A case study in Porcine Survivability through Hemostatic Nanoparticles

Kulkarni, C.·Maisha, N.·Schaub, L. J.·Glaser, J.·Lavik, E.·Janeja, V.
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Abstract

This paper focuses on the analysis of time series representation of blood loss and cytokines in animals experiencing trauma to understand the temporal progression of factors affecting survivability of the animal. Trauma related grave injuries cause exsanguination and lead to death. 50% of deaths especially in the armed forces are due to trauma injuries. Restricting blood loss usually requires the presence of first responders, which is not feasible in certain cases. Hemostatic nanoparticles have been developed to tackle these kinds of situations to help achieve efficient blood coagulation. Hemostatic nanoparticles were administered into trauma induced porcine animals (pigs) to observe impact on the cytokine and blood loss experienced by them. In this paper we present temporal models to study the impact of the hemostatic nanoparticles and provide snapshots about the trend in cytokines and blood loss in the porcine data to study their progression over time. We utilized Piecewise Aggregate Approximation, Similarity based Merging and clustering to evaluate the impact of the different hemostatic nanoparticles administered. In some cases the fluctuations in the cytokines may be too small. So in addition we highlight situations where temporal modelling that produces a smoothed time series may not be useful as it may remove out the noise and miss the overall fluctuations resulting from the nanoparticles. Our results indicate certain nanoparticles stand out and lead to novel hypothesis formation.

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Kulkarni, C., Maisha, N., Schaub, L. J., Glaser, J., Lavik, E., Janeja, V.. 2021-05-26. Temporal Progression: A case study in Porcine Survivability through Hemostatic Nanoparticles. https://doi.org/10.1101/2021.05.25.445617

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