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bioRxiv · 10.1101/2021.05.05.442844

Platform for Incisionless, Focal, and Multisite Brain Interventions

Webb, T. D.·Wilson, M. G.·Odéen, H.·Kubanek, J.
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Abstract

MotivationTranscranial focused ultrasound brings personalized medicine to the human brain. Ultrasound can modulate neural activity or release drugs in specific neural circuits but this personalized approach requires a system that delivers ultrasound into specified targets flexibly and on command. SummaryWe developed a remote ultrasound system (Remus) that programmatically targets deep brain regions with high spatiotemporal precision and in a multi-focal manner. We validated these functions by safely modulating two deep brain nuclei--the left and right lateral geniculate nucleus-in a task-performing non-human primate. This flexible system will enable researchers and clinicians to diagnose and treat specific deep brain circuits in a noninvasive yet targeted manner, thus embodying the promise of personalized treatments of brain disorders. Animated graphical abstract: onetarget.us/download/rem.

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Webb, T. D., Wilson, M. G., Odéen, H., Kubanek, J.. 2021-05-06. Platform for Incisionless, Focal, and Multisite Brain Interventions. https://doi.org/10.1101/2021.05.05.442844

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