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bioRxiv · 10.1101/2021.04.28.441757

Adhesion-growth factor crosstalk regulates AURKB activation and ERK signaling in re-adherent fibroblasts.

Inchanalkar, S.·Balasubramanian, N.
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Abstract

Aurora kinases despite their similarity have distinct roles in the cell cycle, which is regulated by cell-matrix adhesion and growth factors. This study reveals loss of adhesion and re-adhesion to differentially regulate Aurora kinases. AURKB activation that drops on the loss of adhesion recovers on re-adhesion in serum-deprived conditions but not in the presence of serum growth factors. A rapid 30min serum treatment of serum-deprived cells blocks the adhesion-dependent recovery of AURKB, which negatively corelates with Erk activation. AZD mediated inhibition of AURKB in serum-deprived re-adherent cells promotes Erk activation and membrane ruffling, comparable to presence of serum. These studies thus define a novel adhesion-growth factor-dependent regulation of AURKB that controls adhesion-dependent Erk activation in re-adherent fibroblasts.

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Inchanalkar, S., Balasubramanian, N.. 2021-04-29. Adhesion-growth factor crosstalk regulates AURKB activation and ERK signaling in re-adherent fibroblasts.. https://doi.org/10.1101/2021.04.28.441757

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