CMOS electrochemical imaging arrays for thedetection and classification of microorganisms

Arcadia, C. E.; Hu, K.; Epstein, S.; Wanunu, M.; Adler, A.; Rosenstein, J. K.

doi:10.1101/2021.04.21.440070

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bioRxiv · 10.1101/2021.04.21.440070

CMOS electrochemical imaging arrays for thedetection and classification of microorganisms

Arcadia, C. E.·Hu, K.·Epstein, S.·Wanunu, M.·Adler, A.·Rosenstein, J. K.

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Abstract

Microorganisms account for most of the biodiversity on earth. Yet while there are increasingly powerful tools for studying microbial genetic diversity, there are fewer tools for studying microorganisms in their natural environments. In this paper, we present recent advances in CMOS electrochemical imaging arrays for detecting and classifying microorganisms. These microscale sensing platforms can provide non-optical measurements of cell geometries, behaviors, and metabolic markers. We review integrated electronic sensors appropriate for monitoring microbial growth, and present measurements of single-celled algae using a CMOS sensor array with thousands of active pixels. Integrated electrochemical imaging can contribute to improved medical diagnostics and environmental monitoring, as well as discoveries of new microbial populations.

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Arcadia, C. E., Hu, K., Epstein, S., Wanunu, M., Adler, A., Rosenstein, J. K.. 2021-04-22. CMOS electrochemical imaging arrays for thedetection and classification of microorganisms. https://doi.org/10.1101/2021.04.21.440070

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