Eosinophils are dispensable for development of MOG35-55-induced experimental autoimmune encephalomyelitis in mice

Ruppova, K.; Lim, J.-H.; Fodelianaki, G.; August, A.; Neuwirth, A.

doi:10.1101/2021.04.09.439129

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bioRxiv · 10.1101/2021.04.09.439129

Eosinophils are dispensable for development of MOG35-55-induced experimental autoimmune encephalomyelitis in mice

Ruppova, K.·Lim, J.-H.·Fodelianaki, G.·August, A.·Neuwirth, A.

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Abstract

Experimental autoimmune encephalomyelitis (EAE) represents the mouse model of multiple sclerosis, a devastating neurological disorder. EAE development and progression involves the infiltration of different immune cells into the brain and spinal cord. However, less is known about a potential role of eosinophil granulocytes for EAE disease pathogenesis. In the present study, we found enhanced eosinophil abundance accompanied by increased concentration of the eosinophil chemoattractant eotaxin-1 in the spinal cord in the course of EAE induced in C57BL/6 mice by immunization with MOG35-55 peptide. However, the absence of eosinophils did not affect neuroinflammation, demyelination and clinical development or severity of EAE, as assessed in {Delta}dblGATA1 eosinophil-deficient mice. Taken together, despite their enhanced abundance in the inflamed spinal cord during disease progression, eosinophils were dispensable for EAE development.

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Ruppova, K., Lim, J.-H., Fodelianaki, G., August, A., Neuwirth, A.. 2021-04-11. Eosinophils are dispensable for development of MOG35-55-induced experimental autoimmune encephalomyelitis in mice. https://doi.org/10.1101/2021.04.09.439129

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