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bioRxiv · 10.1101/2021.04.03.438329

Cobolt: Joint analysis of multimodal single-cell sequencing data

Gong, B.·Zhou, Y.·Purdom, E.
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Abstract

A growing number of single-cell sequencing platforms enable joint profiling of multiple omics from the same cells. We present Cobolt, a novel method that not only allows for analyzing the data from joint-modality platforms, but provides a coherent framework for the integration of multiple datasets measured on different modalities. We demonstrate its performance on multi-modality data of gene expression and chromatin accessibility and illustrate the integration abilities of Cobolt by jointly analyzing this multi-modality data with single-cell RNA-seq and ATAC-seq datasets.

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Gong, B., Zhou, Y., Purdom, E.. 2021-04-04. Cobolt: Joint analysis of multimodal single-cell sequencing data. https://doi.org/10.1101/2021.04.03.438329

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