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bioRxiv · 10.1101/2021.04.02.437789

Serum CSF1 levels are elevated in patients following partial hepatectomy and acetaminophen induced acute liver failure: Reanalysis of previous data

Stutchfield, B.·Starkey Lewis, P.·Wigmore, S.·Simpson, K.·Hume, D. A.·Forbes, S. J.
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Abstract

A previous study analysed serum CSF1 concentration in patients who had undergone partial hepatectomy and patients with acute liver failure (ALF) induced by acetaminophen. A correlation between low CSF1 and poor prognosis was reported in ALF. In May 2018, an allegation of research misconduct was made against the second author of the published study, D.J.Antoine, who carried out the CSF1 analysis. The current study describes the independent reanalysis of circulating CSF1 concentration in sera from the same patient cohorts. Patient serum CSF1 levels increased following partial hepatectomy. By contrast to the published report, serum CSF1 concentration was greatest in ALF patients who died compared to survivors. The results confirm the relationship between liver injury and circulating serum CSF1.

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Stutchfield, B., Starkey Lewis, P., Wigmore, S., Simpson, K., Hume, D. A., Forbes, S. J.. 2021-04-04. Serum CSF1 levels are elevated in patients following partial hepatectomy and acetaminophen induced acute liver failure: Reanalysis of previous data. https://doi.org/10.1101/2021.04.02.437789

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