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bioRxiv · 10.1101/2021.03.22.436502

VICTOR: A visual analytics web application for comparing cluster sets

Karatzas, E.·Gkonta, M.·Hotova, J.·Baltoumas, F. A.·Kontou, P. I.·Bobotsis, C. J.·Bagos, P. G.·Pavlopoulos, G. A.
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Abstract

Clustering is the process of grouping together different data objects based on similar properties. Clustering has applications in various case studies from several fields such as graph theory, image analysis, pattern recognition, statistics and others. Nowadays, there are numerous algorithms and tools able to generate clustering results. However, different algorithms or parameterization may result in very different clusters. This way, the user is often forced to manually filter and compare these results in order to decide which of them produce the ideal clusters. To automate this process, in this study, we present VICTOR, the first fully interactive and dependency-free visual analytics web application which allows the comparison and visualization of various clustering algorithms. VICTOR can handle multiple clustering results simultaneously and compare them using ten different metrics. Clustering results can be filtered and compared to each other with the use of interactive heatmaps, bar plots, correlation networks, sankey and circos plots. We demonstrate VICTORs functionality using three examples. In the first case, we compare five different algorithms on a protein-protein interaction dataset whereas in the second example, we test four different parameters of the same clustering algorithm applied on the same dataset. Finally, as a third example, we compare four different meta-analyses with hierarchically clustered differentially expressed genes found to be involved in myocardial infarction. VICTOR is available at http://bib.fleming.gr:3838/VICTOR.

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Karatzas, E., Gkonta, M., Hotova, J., Baltoumas, F. A., Kontou, P. I., Bobotsis, C. J., Bagos, P. G., Pavlopoulos, G. A.. 2021-03-23. VICTOR: A visual analytics web application for comparing cluster sets. https://doi.org/10.1101/2021.03.22.436502

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