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bioRxiv · 10.1101/2021.03.17.435721

Implementation and acceleration of optimal control for systems biology

Sharp, J. A.·Burrage, K.·Simpson, M. J.
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Abstract

Optimal control theory provides insight into complex resource allocation decisions. The forward-backward sweep method (FBSM) is an iterative technique commonly implemented to solve two-point boundary value problems (TPBVPs) arising from the application of Pontryagins Maximum Principle (PMP) in optimal control. In this review we discuss the PMP approach to optimal control and the implementation of the FBSM. By conceptualising the FBSM as a fixed point iteration process, we leverage and adapt existing acceleration techniques to improve its rate of convergence. We show that convergence improvement is attainable without prohibitively costly tuning of the acceleration techniques. Further, we demonstrate that these methods can induce convergence where the underlying FBSM fails to converge. All code used in this work to implement the FBSM and acceleration techniques is available on GitHub at https://github.com/Jesse-Sharp/Sharp2021.

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Sharp, J. A., Burrage, K., Simpson, M. J.. 2021-03-17. Implementation and acceleration of optimal control for systems biology. https://doi.org/10.1101/2021.03.17.435721

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